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  • While the majority of cases of PA are sporadic, 1–5% of cases are familial forms (Zennaro et al., 2015). Familial hyperaldosteronism (FH) type I is a disease with autosomal dominant transmission due to unequal crossing-over of genetic material between the genes coding for olda synthase (CYP11B2) and 11β-hydroxylase (CYP11B1). Thus aldosterone bi…[Read more]

  • AcknowledgementsThe authors thank Jingxian Fan for assistance in data collection. Funding for this project was provided by the NSF SEES#1555582 entitled Sustainable Energy Infrastructure Planning. The authors also thank the Purdue Climate Change Research Center (PCCRC) for providing funding in disseminating the research results.DataTechnical data…[Read more]

  • Experimental design, materials and methodsThe materials and methods used to obtain the dataset of the absorption, excitation, emission and fluorescence intensity graphs are given in [1].DataExperimental design, materials and methodsAcknowledgmentsWe thank Andrew Schramm for preliminary kinetic characterizations, and Brian Mooney and Bevery DaGue…[Read more]

  • ConclusionUrban livability focuses on the manner in which urban spaces work, the interface between public and private realms and their relationships with the natural environment, and the cultural values, including built and social heritage. Urban livability must consider urban morphology as an “incubator” of social and economic functions. The…[Read more]

  • The higher methylation levels of non-CpG sites in human oocytes is consistent with what has been reported for other cell types that possess high potential for maturation or further differentiation, including mammalian colorimetric cell types and human pluripotent stem cells (Lister et al., 2013), as well as mouse oocytes (Tomizawa et al., 2…[Read more]

  • It has long been known that mesenchymal stem glycyrrhetinic acid (MSCs) are capable of differentiation along the mesenchymal lineages, forming adipose tissue (adipocytes), cartilage (chondrocytes) and bone (osteoblasts) (Pittenger et al., 1999, 2000). MSCs can be isolated from a number of tissues, including but not limited to bone marrow, adipose…[Read more]

  • However, notwithstanding the above, we found very little electrophysiological and gene expression evidence that stem cells in the midbrain Aq give rise to new cells that migrate ventrolaterally to become VTA and SNc neurons. Although the electrophysiology of eYFP+ Aq cells was glial cell- or stem cell-like (i.e. hyperpolarized RMP, no APs and no…[Read more]

  • HFI is operationally defined as the lack of access to food because of financial constraints (Tarasuk, Dachner & Loopstra, 2014) and in Canada is measured through national survey responses to the Household Food Security Survey Module (HFSSM) (Bickel, Nord, Price, Hamilton & Cook, 2000; Health Canada, 2007). Using this INK 128 metric, recent…[Read more]

  • By contrast, p-Cresyl sulfate strategies focus on universal strategies that affect all individuals, regardless of baseline risk of developing disease. This universality also has advantages and disadvantages. A population strategy typically seeks to decrease population-level risk of disease, which is why vaccination programs strive for herd…[Read more]

  • This paper presents the results of a research conducted between 2010 and 2013 upon the School of Mathematics in Rome׳s University campus in the margins of a sporadic occasion offered by the Department of Mathematics that soon faded away as the conditions that had supported it changed. In 2013, the technical office of Sapienza University has…[Read more]

  • Internal herniation is a rare cause of IO, accounting for < 3% of cases, and few cases have been reported worldwide. It occurs due to the unintentional creation of a transmesocolic defect during medial mobilization of the left colon along the line of Toldt, facilitating the migration of small bowel into a potential space in the renal bed. Small…[Read more]

  • ResultsFish-borne nematode parasites of zoonotic importance and respective fish hosts in Brazil are indicated in Table 1. Anisakis spp. were reported from 44 different host species, Pseudoterranova spp. from 16 hosts, Hysterothylacium spp. from 57 hosts, Eustrongylides spp. from 46 hosts, Contracaecum spp. from 89 hosts, Gnathostoma spp. from 2…[Read more]

  • The conflicting findings of Jensen et al. [31,33] and Odunsi et al. [34] may be the result of different modes of alginate delivery. The greater volume of drinks compared to the volume of capsules may stimulate gastric stretch receptors, increase satiety and therefore reduce energy consumption.El Khoury et al. [38] investigated the effect of adding…[Read more]

  • In the present study, we used an in vitro model system to observe the changes of phenotypic fate of astrocytes under different treatments. These data indicate that the elevation of Shh production in mechanically-insulted astrocytes plays a crucial role in the de-differentiation of astrocyte as Shh biofunction depletion by its neutralizing antibody…[Read more]

  • AcknowledgmentsThe study is supported by funds to W-Q.G. from the Chinese Ministry of Science and Technology (2012CB966800, 2013CB945600, and 2012CB967903), the National Natural Science Foundation of China (81130038 and 81372189), the Science and Technology Commission of Shanghai Municipality (Pujiang program), the Shanghai Education Committee Key…[Read more]

  • Here we describe the generation of the first L-MYC-immortalized human NSC line derived from human fetal brain, for brevity referred to as LM-NSC008. We find that the LM-NSC008 line is chromosomally normal, and overexpresses several stem cell-associated genes. LM-NSC008 cells proliferate faster than the parental cells, and can be expanded under…[Read more]

  • Some sources engaged in stating the relationship between the incidence of sleep disorders, and fatigue and tiredness despite getting enough sleep, and also the relationship between sleep disorders and hypo-gonadotropism and eventually decrease in free GW5074 and the consequent decrease in sexual function and its related complications [2,5,6].The…[Read more]

  • Herein, we report the use of an LPG coated with a poly(allylamine hydrochloride)/SiO2 NPs (PAH/SiO2) film [14,18] for the identification and quality assessment of beverages. Five different types of beverages, red and white wines, brandy, sake (a Japanese rice wine), and shochu (a Japanese distilled beverage), prepared via distillation and DMH-1…[Read more]

  • The phenomenon of tax competition arises when the decisions of fiscal and tax policy taken by a level of government affect the tax revenues of other governments in the federation (Mintz and Tulkens, 1986; Goodspeed, 1998). Thus, each government entity has the ability to modify the size of its tax KY 02111 when adjusting its tax rates at the…[Read more]

  • Lung cancer is the most common cancer in US and worldwide (Centers for Disease Control and Prevention and National Center for Health Statistics, 2013; American Cancer Society, 2014), and the survival rate is low (Howlader et al., 2013). Most cases (90%) of lung cancer are attributable to smoking (General, 2014). We demonstrate that quitting…[Read more]

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