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  • Importantly, we observed that there is variability of sleep concordance across dyads. This variability indicates that not all adolescents are necessarily tuned with their parents. That is, sleep and neural connectivity patterns developed in adolescents are not based solely on the sleep and neural connectivity patterns of their parents. Adolescence…[Read more]

  • The XRD was carried out using Cr-Kα radiation X-ray tube operating with a target current of 7 mA at 30 kV (Model: Rigaku MSF 2M). The ψ angles were tilted in steps of 9° in the range of 0° to 45°. The residual stresses were estimated using the peak shift at ψ angles and d-spacing relationship of (211) plane. Scanning was done in the angular r…[Read more]

  • FUS, also known as Translocated in Liposarcoma (TLS), is a DNA/RNA-binding protein containing a glycine-rich region, an RNA recognition motif and a nuclear localization signal (Lattante et al., 2013; Yang et al., 2010). In FALS, more than 50 mutations in the FUS gene have been reported (Lattante et al., 2013). Some mutant FUS proteins form nu…[Read more]

  • A limited number of studies have evaluated primary cultures of undifferentiated spermatogonia established from adult mice (Schmidt et al., 2011; Seandel et al., 2007), but the relative SSC content and regenerative integrity over an extended period of in vitro proliferation have not been reported. Indeed, a majority of studies regarding culture of…[Read more]

  • For suicidal ideations, plans and attempts, interpersonal level risk factors that were found to be significant were being bullied, physically attacked and being involved in a physical fight. These findings are consistent with other studies (e.g., Randall et al., 2014; Shilubane et al., 2013; 2014; Swahn et al., 2012). The association between…[Read more]

  • DiscussionDespite the recent publication of the National Sleep Foundation’s Sleep duration team recommendations [1], sleep deprivation is recognized as important to public health. Industrial accidents, motor vehicle crashes and medical and other occupational errors have been associated with sleep deprivation. [2,3]. Moreover, sleep deprived s…[Read more]

  • The knowledge about Taspase1 and its particular activation mechanism was subsequently used to design a dominant-negative variant of Taspase1 (dnTASP1). This mutant combines the S291A and C163E mutations. Therefore, such a mutant monomer — per se unable to become activated itself — binds with the modified docking head to other Taspase1 monomers and…[Read more]

  • In this study, we investigated changes in MMP concentrations on ART and the association between these changes and paradoxical TB-IRIS in a well-characterized cohort of HIV-infected adults with advanced HIV/TB (Ravimohan et al. 2013; Ravimohan et al. 2015a). Furthermore, in a subset of patients, we explored the relationship between the magnitude of…[Read more]

  • Cancer stem OG-L002 (CSCs) are a subpopulation of tumor cells with stem cell like features in solid malignancies, which play an important role in cancer recurrence and metastasis. Breast cancer patients with an elevated proportion of cancer stem cells identified by immunostaining for markers of breast cancer stem cell (BCSC), including ALDH1 and…[Read more]

  • Although low baseline virus load is considered one of the predictive factors for SVR12, many other host, virus and drug related factors are also important and can sometimes affect the virus response to treatment regardless of baseline virus load. The significant existence of Resistance Associated Substitutions (RASs) is an example of an…[Read more]

  • IntroductionThe global emergence of resistance to antimicrobial agents is increasingly limiting the effectiveness of current drugs, especially in immuno compromised patients. Drug resistance, especially by bacteria and fungi, is one of the major concerns to public health and scientific communities’ worldwide [1,2]. To overcome the microbial r…[Read more]

  • Targeting experiments with a second eGFP reporter cell line (hCBiPS2eGFPC16) showed similar results. The observed 3-fold lower eGFP gene targeting efficiency for hCBiPS2eGFPC16 as compared with hCBiPS2eGFPC7 cells most likely represents clone-specific variations with respect to survival rates after single-cell dissociation, transfection…[Read more]

  • We show that the PB transposon and its transposase are functional and quite efficient in terms of stable gene transfer to primary mesoangioblasts when compared to the transfection of plasmid vectors. Transposition occurred even when using large transposons comprising two expression cassettes and a spacer or MAR element. The decrease of…[Read more]

  • The determinants of happinessThe definition of happiness may have different concepts and denominations. Consistency tests have been developed by some psychologists, revealing that happy people are more optimistic, more sociable, more extroverted, and enjoy better sleep (Frey and Stutzer, 2008). For Veenhoven (2007), the term happiness, oftentimes…[Read more]

  • To determine the potential mechanisms of C5a generation in vivo, we used in vitro assays in purified systems to compare C5a generation following cleavage of C5 by thrombin, factor Xa or plasmin. Plasmin was considered a likely candidate of complement activation in the setting of a fibrin clot because, 1) plasmin is known to cleave C5 to yield…[Read more]

  • Material and MethodsResultsDiscussionOne key component of meditation is the open, non-judgmental attitude towards internal and external experiences, which, when coupled with a self-detached evaluative approach, can ultimately lead to stimuli and events being perceived as neither ‘good’ nor ‘bad’, but rather as even entities devoid of subject…[Read more]

  • Flash X-ray cinematography set-upA schematic of the measurement set-up for flash X-ray cinematography is shown in Fig. 1. Instead of several separate X-ray tubes one multi-anode 450 kV tube is utilized. In the multi-anode tube eight anodes are arranged on a circle of ≈12 cm diameter. This configuration causes only a relatively small parall…[Read more]

  • Esto explica que en México sea escasa la publicación de libros y artículos en torno Bisindolylmaleimide V manufacturer la disputa por la “prostitución”. Existen, sin duda, espléndidas investigaciones históricas sobre la “prostitución” y muy serias investigaciones sobre distintos aspectos del comercio sexual, además de los trabajos clásicos sobre…[Read more]

  • IntroductionThere is increasing interest in exploring complex freeform shapes in contemporary architectural and design practice. Frank Gehry (Lindsey, 2001) and Zaha Hadid (Jodidio, 2009) are prime examples of pioneering avant-garde designers who have incorporated freeform shapes into their designs. The development of manifesting freeform designs…[Read more]

  • With regard to subdural hematoma, the most widely accepted theory is that of Russel and colleagues, who have suggested that impaired blood perfusion occurs because of tumor embolism in the dural vein, thereby causing the dilation and breakdown of capillary vessels, resulting in subdural hematoma. Subdural hematomas in this setting could be…[Read more]

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