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  • The results of analyses of all included SNPs on CPD in the WHI SHARe sample are presented in Table 2. In the models with CPD as their outcome in the WHI SHARe cohort, 1 SNP was found to be associated with CPD following Bonferroni adjustment), rs1051730 (adjusted p=0.027). For this SNP, each additional A allele increased subjects’ expected number…[Read more]

  • HEV may also contribute to various extrahepatic manifestations, including pancreatitis, hematological disorders (thrombocytopenia and anemia), kidney disorders and neurological complications (Guillain-Barré syndrome and meningoencephalitis) (Singh and Gangappa, 2007; Thapa et al., 2009; Wedemeyer et al., 2012). The discovery of HEV quasispecies…[Read more]

  • Experimental design, materials, and methodsWe investigated the growth of illegal settlements on the frontiers of urbanization in Mexico City using a combination of human observation (VGI) and remote sensing (see Fig. 2). A graphical abstract can be found in the associated publication [4]. In the following analysis, statistically significant…[Read more]

  • Brin Hartley posted an update 1 day, 5 hours ago

    DataThese data mainly focus on the dose-dependent neuroprotection provided by baclofen, memantine and l-carnitine against oxygen-glucose-deprivation (OGD)-related neurodegeneration of CA1 region, with an addition of the data obtained from the use of hypothermia instead of pharmacological agents. The data consists of CA1 stratum pyramidale (CA1sp)…[Read more]

  • Brin Hartley posted an update 1 day, 7 hours ago

    En 1974, cuando la revista sale regadenoson la luz, gobernaba la otra señora de Perón, la otra Perona. No afirmamos ninguna coincidencia lógica, tan sólo cronológica. En el primer número de Persona, una foto de Isabel Perón va acompañada del siguiente texto:En negrita, la página de apoyo y referencia a Isabel Perón dice “Las mujeres argentinas…[Read more]

  • Brin Hartley posted an update 1 day, 8 hours ago

    A survey in manufacturing and product design innovation conducted by O’Sullivan (2002) revealed several causes of failure in organizations, such as poor leadership, poor organization, poor communication, poor empowerment, and poor knowledge management. Other factors include failure, which is an inevitable part of the innovation process. Most s…[Read more]

  • Brin Hartley posted an update 1 day, 9 hours ago

    Analgesia is an important ancillary property of all anti-inflammatory agents. Most of the anti-inflammatory drugs increased pain threshold in various animal models [44]. This is natural because many endogenous chemical mediators of inflammation play a part in generating pain impulses (for example, histamine, serotonin and prostaglandins) and some…[Read more]

  • Brin Hartley posted an update 1 day, 9 hours ago

    The difficulty of applying methods developed in mouse ESCs to hESCs likely reflects a critical difference in the default identity of NPCs generated from the two different species. Sonic hedgehog (Shh) signaling predominates in the mouse system, whereas WNT signaling predominates in human cells, resulting in NPCs with a default ventral (mouse)…[Read more]

  • The molecular mechanisms controlling the establishment of imprinting at the GNAS cluster and leading to the methylation defects in PHP1B are mostly unknown, in part because of a paucity of suitable animal models and lack of accessible Gsα-imprinted human tissues. During the murine embryonic development, the differential methylation of exon 1A…[Read more]

  • ResultsDiscussionExperimental transdifferentiation of buy PF-2341066 by ectopic expression of conditional C/EBPα has shed light on the molecular dynamics of the conversion of lymphoid cells into inflammatory macrophages (Bussmann et al., 2009; Di Tullio et al., 2011; Krijger et al., 2016; Laiosa et al., 2006; Rodriguez-Ubreva et al., 2012, 2014;…[Read more]

  • There are several policy implications for these results. Since 2006 in an attempt to reduce financial barriers, delivery care has been exempt from user fees in Burkina Faso (Ridde, Richard, Bicaba, Queuille, & Conombo, 2011). While user fee reductions have been shown to increase service coverage, many women continued to deliver at home…[Read more]

  • AcknowledgmentsThe authors are thankful to the financial support of the Regional Attention and Action for Knowledge (RAAK) circulation scheme, which is managed by the Foundation Innovation Alliance (Stichting Innovatie Alliantie, SIA) with funding from the Dutch Ministry of Education, Culture, and Science (SIA project number 2014-01-05P, Project…[Read more]

  • In the discussion of vernacular architecture, ambiguities arise from the meanings of certain terms and concepts. The words “modern” and “traditional” are often considered as being in fundamental opposition to each other. One tends to suppose that vernacular architecture is a kind of traditional architecture, distinct from modern archite…[Read more]

  • ConclusionIntroductionPilocytic astrocytoma (PCA; WHO Grade 1) has a benign biologic behavior and carries one of the highest survival rates among all types of astrocytoma. However, it occasionally shows atypical behavior characterized by local recurrence or, rarely, by malignant transformation and metastatic spread. The dissemination of low-grade…[Read more]

  • Morphology and diagnosisMacroscopic inspection of the anisakid larvae may reveal some minor differences between the parasites. A. simplex larvae are whitish to transparent (Fig. 1A), P. decipiens larvae are reddish to brownish (Fig. 1B) and C. osculatum larvae appear transparent via greyish to brownish (Fig. 1C). Specific diagnosis is not possible…[Read more]

  • Key problems that need to be resolved to understand the relationship between foods and healthIn term of the relationship between foods and health, the following four key problems have to be addressed: (1) Undernutrition causes nutrition deficiency, and overnutrition leads to obesity, hypertension, hyperlipidemia, diabetes, and cancer. It also…[Read more]

  • ResultsDiscussionAs the first step of our method, hiPS cells underwent differentiation into definitive endoderm by treatment with activin A and the GSK3β inhibitor CHIR99021. In other methods, activin A and Wnt 3a have mainly been used to induce definitive endoderm (D’Amour et al., 2006; Kroon et al., 2008; Maehr et al., 2009; Chen et al., 2009;…[Read more]

  • Zscan4 is sometimes considered as a marker of highly pluripotent status, merely due to its expression at the two-cell stage during development (Cerulo et al., 2014). However, based on our observation, we would like to propose that the expression of Zscan4 is activated in response to telomere shortening and maybe to DNA damage, independent of the…[Read more]

  • These data suggest that niches are not limited to the governance of stem cells (Wu et al., 2009; Yu et al., 2015a), and the definition of “progenitor niches” may offer new ways to understand the regulation of tissue composition and function. We recently demonstrated that selective deletion of cells expressing the mature osteolineage cell marke…[Read more]

  • DiscussionDespite the recent publication of the National Sleep Foundation’s Sleep duration team recommendations [1], sleep deprivation is recognized as important to public health. Industrial accidents, motor vehicle crashes and medical and other occupational errors have been associated with sleep deprivation. [2,3]. Moreover, sleep deprived s…[Read more]

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